abstract：BACKGROUND:Magnetic resonance imaging (MRI) accuracy after neoadjuvant systemic therapy (NST) for breast cancer varies according to hormone receptor (HR), human epidermal growth factor receptor type-2 (HER2) subtype and Ki-67 proliferation index. Whether MRI accuracy varies by genomic signatures is unknown. We examined...

journal_title：Internal medicine journal

authors： Murphy C,Mukaro V,Tobler R,Asher R,Gibbs E,West L,Giuffre B,Baron-Hay S,Khasraw M

更新日期：2018-06-01 00:00:00

abstract：:This study aimed to identify the incidence of perioperative acute upper gastrointestinal bleeding (UGIB) in our hip fracture patients; to evaluate the characteristics, management and clinical outcomes of these patients; and to explore risk factors and protective factors. Of the 1691 consecutive patients admitted for s...

journal_title：Internal medicine journal

authors： Liu J,Gupta R,Hay K,Pulle C,Rahman T,Pandy S

更新日期：2018-06-01 00:00:00

abstract：:Thrombotic microangiopathy (TMA) arises in a variety of clinical circumstances with the potential to cause significant dysfunction of the kidneys, brain, gastrointestinal tract and heart. TMA should be considered in all patients with thrombocytopenia and anaemia, with an immediate request to the haematology laboratory...

journal_title：Internal medicine journal

authors： Fox LC,Cohney SJ,Kausman JY,Shortt J,Hughes PD,Wood EM,Isbel NM,de Malmanche T,Durkan A,Hissaria P,Blombery P,Barbour TD

更新日期：2018-06-01 00:00:00

abstract：:(Neo)adjuvant chemotherapy for early stage breast cancer is associated with side-effects, resulting in increased emergency department (ED) presentations. Treatment-related toxicity can affect quality of life, compromise chemotherapy delivery and treatment outcomes, and increase healthcare use. We performed a retrospec...

journal_title：Internal medicine journal

authors： Tang M,Horsley P,Lewis CR

更新日期：2018-05-01 00:00:00

abstract：:Doctor-patient language discordance has been shown to lead to worse clinical outcomes. In this study of patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction at an Australian health service, we demonstrated that limited English proficiency (LEP) is an independent predict...

journal_title：Internal medicine journal

authors： Biswas S,Seman M,Cox N,Neil C,Brennan A,Dinh D,Walton A,Chan W,Lefkovits J,Reid C,Stub D

更新日期：2018-04-01 00:00:00

abstract：:A 22-year-old woman presented with methanol toxicity manifesting as headache, reduced conscious state and visual change after consuming home-made grappa. She progressed to a coma with fixed mydriasis and severe acidaemia (pH 6.55). She was treated with empirical antidote administration (intravenous ethanol) and enhanc...

journal_title：Internal medicine journal

authors： Holt NR,Nickson CP

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Infections and antibiotic resistance patterns in patients attending regional Australian cancer centres are poorly described. AIMS:To document patient characteristics, infection types, patterns of antibiotic resistance and outcomes in all patients with cancer requiring inpatient management for suspected infe...

journal_title：Internal medicine journal

authors： De Silva N,Jackson J,Steer C

更新日期：2018-03-01 00:00:00

abstract：:We documented temporal changes in the use of lipid-lowering medications and achievement of cholesterol targets in an Australian diabetes clinic. The number of patients using lipid-lowering therapy for primary or secondary cardiovascular prevention increased from 6 to 69% between 1993-1995 and 2014-2016, which correspo...

journal_title：Internal medicine journal

authors： Kiburg KV,Ward GM,O'Neal DN,MacIsaac RJ

更新日期：2018-02-01 00:00:00

abstract：:A case of metformin encephalopathy is presented in a patient on haemodialysis for end-stage diabetic renal failure. The patient presented with frequent falls and clinical signs of Parkinsonism, on a background of recent anorexia and significant weight loss. Magnetic resonance imaging showed bilateral, symmetrical abno...

journal_title：Internal medicine journal

authors： McGarvey C,Franconi C,Prentice D,Bynevelt M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Effective tuberculosis (TB) control relies on early diagnosis and prompt treatment commencement. AIM:To investigate delays in presentation and diagnosis of pulmonary TB (PTB) in a low incidence setting in Western Melbourne. METHODS:A single-centred retrospective observational cohort study of symptomatic pa...

journal_title：Internal medicine journal

authors： Williams E,Cheng AC,Lane GP,Guy SD

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a common cause of incidental liver test abnormalities. General practitioners (GP) have a key role in identifying people with NAFLD at risk of significant liver disease. Recent specialist guidelines emphasise the use of fibrosis algorithms or serum biomarkers rathe...

journal_title：Internal medicine journal

authors： Patel PJ,Banh X,Horsfall LU,Hayward KL,Hossain F,Johnson T,Stuart KA,Brown NN,Saad N,Clouston A,Irvine KM,Russell AW,Valery PC,Williams S,Powell EE

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Management of adrenal incidentalomas (AI) is becoming more conservative, based on international data showing a low incidence of functional or malignant lesions. The clinical characteristics of AI in New Zealand are unknown. Therefore, whether the AI guidelines apply to the New Zealand population is also unkn...

journal_title：Internal medicine journal

authors： Goh Z,Phillips I,Hunt PJ,Soule S,Cawood TJ

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes (T2D) in young adults is associated with a high risk of diabetes complications. AIMS:To investigated the demography and the emergence of complications of young adults with T2D in the central Auckland region where there has been substantial immigration. METHODS:In total, 310 young adults wit...

journal_title：Internal medicine journal

authors： Beig J,Khanolkar M,Cundy T

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Pulmonary embolism (PE) is associated with significant morbidity and mortality. PE is a heterogeneous entity that causes a wide variety of clinical presentations, making it imperative to establish which clinical symptoms, signs and biomarkers can influence the pretest probability of PE to aid clinicians and ...

journal_title：Internal medicine journal

authors： Sethwala A,Wang X,Sturm EE,Collins KL,O'Donnabhain R,Friedman ND

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Increasing numbers of patients receiving new oral anticoagulants (NOAC) are undergoing elective surgery. The extent to which perioperative interruption of NOAC therapy and use of bridging heparin are concordant with best evidence is uncertain. AIMS:To determine: (i) concordance of NOAC and bridging heparin ...

journal_title：Internal medicine journal

authors： Wamala H,Scott IA,Caney X

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukaemia (CLL) frequently responds to chemoimmunotherapy combining cytotoxic chemotherapy and monoclonal antibodies. However, CLL is associated with significant genetic heterogeneity, and some high-risk forms are known to be chemo-resistant and associated with early relapse. AIMS:To rev...

journal_title：Internal medicine journal

authors： Kuss BJ,Tam CS

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The international literature advocates for cancer screening in newly diagnosed patients with autoimmune myositis; however, there is no widely accepted consensus or guideline to outline the optimal cancer screening strategy and the evidence is currently insufficient to support any recommendation. AIM:Our stu...

journal_title：Internal medicine journal

authors： Dutton K,Soden M

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) is a subgroup of oncogene addicted lung cancer that predicts response to tyrosine kinase inhibitors (TKI). However, there is variability in response and survival outcomes in patients with EGFR mutation treated with TKI. AIM:T...

journal_title：Internal medicine journal

authors： Ding PN,Roberts TL,Chua W,Becker TM,Descallar J,Yip PY,Bray V

更新日期：2017-12-01 00:00:00

abstract：:A prospective study of non-invasive ventilation at The Prince Charles Hospital outside of the intensive care unit from March 2015 to March 2016 was performed. Overall 69 patients were included. Acute hypercapnic respiratory failure was the most common indication (n = 59; 85%). 49 (71%) had multifactorial respiratory f...

journal_title：Internal medicine journal

authors： Smith DB,Tay GTP,Hay K,Antony J,Bell B,Kinnear FB,Curtin DL,Douglas J

更新日期：2017-12-01 00:00:00

abstract：:The Australian National Chronic Obstructive Pulmonary Disease (COPD) guidelines recommend that inhaled corticosteroids (ICS) be reserved for patients with a post-bronchodilator forced expiratory volume in 1 s (FEV1 ) less than 50% predicted and those who experience ≥2 exacerbations in 12 months. In total, 707 COPD pat...

journal_title：Internal medicine journal

authors： Harrison A,Borg B,Thompson B,Hew M,Dabscheck E

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:There is little research and no clear guidelines for clinicians to follow when instructing patients with advanced disease about driving. AIMS:To investigate current practice in providing advice to patients with advanced disease and identify areas of consensus or variation with the Australian driving guideli...

journal_title：Internal medicine journal

authors： Weir N,Fischer A,Good P

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:While medications may prolong life and prevent morbidity in older people, adverse effects of polypharmacy are increasingly recognised. As patients age and become frail, prescribing may be expected to focus more on symptom control and minimise potentially harmful preventive medication use that confer little b...

journal_title：Internal medicine journal

authors： Ilango S,Pillans P,Peel NM,Scott I,Gray LC,Hubbard RE

更新日期：2017-09-01 00:00:00

abstract：:In Australia, mutations in epidermal growth factor mutations (EGFR) occur in 15% of patients diagnosed with non-small-cell lung cancer and are found with higher frequency in female, non-smokers of Asian ethnicity. Activating mutations in the EGFR gene are rarely described in SCLC. We present two cases of de novo EGFR ...

journal_title：Internal medicine journal

authors： Thai A,Chia PL,Russell PA,Do H,Dobrovic A,Mitchell P,John T

更新日期：2017-09-01 00:00:00

abstract：:Significant developments have occurred in the discipline of palliative care in the modern era. This paper shall explore those developments, challenge some widely held misconceptions about the role and daily practice of the discipline, highlight the growing recognition of the role of palliative care in non-malignant di...

journal_title：Internal medicine journal

authors： Brennan F

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/AIM:In patients discharged from an Older Person's Health hospital, we assessed (i) the prevalence of anticholinergic medications (ACM) in this study population and (ii) changes in anticholinergic drug burden during admission using the Anticholinergic Drug Scale (ADS). METHODS:Cases were identified between S...

journal_title：Internal medicine journal

authors： Lee MSS,Hanger HC

更新日期：2017-06-01 00:00:00

abstract：:Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are an increasingly prescribed class of medication for type 2 diabetes mellitus. Euglycaemic diabetic ketoacidosis (euDKA) has been reported in association with SGLT2i use. Clinicians need to understand how to recognise and treat this complication. We describe three ...

journal_title：Internal medicine journal

authors： Isaacs M,Tonks KT,Greenfield JR

更新日期：2017-06-01 00:00:00

abstract：:Individualised drug dosing has been shown to improve patient outcomes and reduce adverse drug events. One method of individualised medicine is the Bayesian approach, which uses prior information about how the population responds to therapy, to inform clinicians about how a specific individual is responding to their cu...

journal_title：Internal medicine journal

authors： Donagher J,Martin JH,Barras MA

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Bronchial thermoplasty (BT) is an approved bronchoscopic intervention for the treatment of severe asthma. However, limited published experience exists outside of clinical trials regarding patient selection and outcomes achieved. AIMS:To evaluate the effectiveness and safety of BT in patients with severe ast...

journal_title：Internal medicine journal

authors： Langton D,Sha J,Ing A,Fielding D,Wood E

更新日期：2017-05-01 00:00:00

abstract：:Autoimmune inflammatory rheumatic diseases (AIIRD), such as rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis are often complicated by infection, which results in significant morbidity and mortality. The increased risk of infection is probably due to a combination of immunosuppressive effects of the...

journal_title：Internal medicine journal

authors： Wong PKK,Bagga H,Barrett C,Hanrahan P,Johnson D,Katrib A,Leder K,Marabani M,Pentony P,Riordan J,White R,Young L

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:There is no mechanism in place for monitoring or quality improvement of cancer multidisciplinary meetings (MDM) in Australia. AIM:To develop a peer-review process for quality improvement of MDM. METHODS:This project involved three phases: (i) development of a draft peer-review framework, supporting documen...

journal_title：Internal medicine journal

authors： Johnson CE,Slavova-Azmanova N,Saunders C

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Trends in the incidence of acute myocardial infarction (AMI) provide important information for healthcare providers and can allow for accurate planning of future health needs and targeted interventions in areas with an excess burden of cardiovascular disease. AIM:To investigate the regional variations in AM...

journal_title：Internal medicine journal

authors： Davies AJ,Naudin C,Al-Omary M,Khan A,Oldmeadow C,Jones M,Bastian B,Bhagwandeen R,Fletcher P,Leitch J,Boyle A

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The role of brentuximab peri-allogeneic transplantation in patients with relapsed and/or refractory CD30 positive lymphomas remains poorly defined. AIM:To assess the outcome of use of brentuximab as a bridge to allogeneic stem cell transplantation (SCT) in patient with relapsed/refractory CD30+ classic Hodg...

journal_title：Internal medicine journal

authors： Mediwake H,Morris K,Curley C,Butler J,Kennedy G

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:In recent years, there has been a significant increase in the number of cancer treatments that have become available. However, it has remained difficult to choose the most appropriate time to cease active therapy in individual patients. AIMS:To determine the proportion of patients being treated with palliat...

journal_title：Internal medicine journal

authors： Wein L,Rowe C,Brady B,Handolias D,Lipton L,Pook D,Stanley R,Haines I

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia occurring in 2% of the population. It is known that AF increases morbidity and limits quality of life. The CHA2 DS2 VASc score (congestive heart failure/left ventricular dysfunction, hypertension, age ≥75 (doubled), diabetes, stroke (doubled), vascular d...

journal_title：Internal medicine journal

authors： Mlodawska E,Tomaszuk-Kazberuk A,Lopatowska P,Kaminski M,Musial WJ

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The ACT Genetic Service at The Canberra Hospital evaluates the genetic risk of individuals for inherited diseases, and provides counselling and genetic testing where appropriate. AIM:To evaluate the current referral practice for patients with a personal and/or family history of breast and/or ovarian cancer,...

journal_title：Internal medicine journal

authors： Aitken L,Warwick L,Davis A

更新日期：2017-03-01 00:00:00

abstract：:A cross-sectional survey of 265 adult patients with haematological malignancy, haemoglobinopathy or human immunodeficiency virus was performed to determine the potential risk of infection from animal exposures. One hundred and thirty-seven (52%) owned an animal; the majority were dogs (74%) and cats (39%), but 14% own...

journal_title：Internal medicine journal

authors： Gurry GA,Campion V,Premawardena C,Woolley I,Shortt J,Bowden DK,Kaplan Z,Dendle C

更新日期：2017-03-01 00:00:00

abstract：:It is generally accepted that the prevalence of food allergy has been increasing in recent decades, particularly in westernised countries, yet high-quality evidence that is based on challenge confirmed diagnosis of food allergy to support this assumption is lacking because of the high cost and potential risks associat...

journal_title：Internal medicine journal

authors： Tang ML,Mullins RJ

更新日期：2017-03-01 00:00:00

abstract：:Waldenström macroglobulinaemia (WM) is an indolent B-cell malignancy characterised by the presence of immunoglobulin M (IgM) paraprotein and bone marrow infiltration by clonal small B lymphocytes, plasmacytoid lymphocytes and plasma cells. The symptoms of WM are protean, often follow an asymptomatic phase and may incl...

journal_title：Internal medicine journal

authors： Talaulikar D,Tam CS,Joshua D,Ho JP,Szer J,Quach H,Spencer A,Harrison S,Mollee P,Roberts AW,Horvath N,Lee C,Zannettino A,Brown R,Augustson B,Jaksic W,Gibson J,Kalff A,Johnston A,Trotman J,Kalro A,Grigoriadis G,

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Glomerular M-type phospholipase A2 receptor (PLA2 R) is important for diagnosing idiopathic membranous nephropathy (IMN). The relation between glomerular PLA2 R expression and response to treatment remains to be explored. AIMS:We conducted the study to explore the positive rate and clinical significance of ...

journal_title：Internal medicine journal

authors： Liu H,Luo W,Gong S,Ding X

更新日期：2016-11-01 00:00:00

abstract：:Prior randomised studies of immunoglobulin replacement therapy have studied mixed populations with or without a history of infections. Immunoglobulin therapy is expensive and in limited supply suggesting that optimising patient selection is of value. In this retrospective study, infection history identified high-risk ...

journal_title：Internal medicine journal

authors： Paxton L,Hawkins C,Crispin P

更新日期：2016-10-01 00:00:00